OSMF ships everything to your door — supplements, pulse oximeter, and test strips. You participate from home, on your schedule, using your smartphone. No clinic visits required.
20 spots available. We'll be in touch within 48 hours with next steps.
Trial Sponsor
Our mission is to identify effective therapeutics for PACVS and to deepen the scientific understanding of post-viral illness — producing open-access evidence that patients, clinicians, and researchers can act on. opensourcemed.info →
Everything arrives at your door. You do the protocol at home. We collect the data. No flights, no clinic visits.
Submit your interest below. We'll send a screening questionnaire within 48 hours. If you qualify, we'll be in touch with next steps and an informed consent form.
Three labelled gallon bags ship to your door within 7–10 days — supplements, pulse oximeter, test strips, and a protocol instruction card.
Take your supplements daily. Complete weekly NO strip readings, monthly step tests, and daily symptom check-ins via our app — all from home.
Your data feeds a peer-reviewed publication. All participants receive a full personal report of their results at trial completion.
Three labelled gallon bags ship directly to your home. Everything you need for 90 days is included.
Pre-measured powder blends. Mix your daily dose with water or juice each morning. Includes a calibrated measuring scoop.
Wellue PC-60FW Bluetooth pulse oximeter for SpO₂ and heart rate logging, with CSV export for data submission. Batteries included.
13 salivary nitric oxide strips for weekly fasting measurements, plus a laminated protocol card with step test instructions and QR code to the data app.
This is a fully decentralized trial — designed for people who are too ill to travel or who live far from research centres. Your participation is 100% home-based.
PACVS describes a constellation of persistent symptoms arising after COVID-19 vaccination, overlapping substantially with ME/CFS and Long COVID. It is under-researched, underdiagnosed, and currently lacks any approved treatment.
OSMF's research focuses on the two most mechanistically supported pathways: endothelial nitric oxide dysregulation and mitochondrial oxidative capacity impairment — both of which can be measured non-invasively at home.
Endothelial cells in PACVS patients produce significantly less nitric oxide, impairing vasodilation, tissue oxygenation, and mitochondrial function. Our protocol targets the enterosalivary NO pathway with arginine, citrulline, and serine — measurable via weekly salivary NO strips.
PACVS patients show impaired beta-oxidation and elevated lactate accumulation at low exercise intensities, indicating the anaerobic threshold is reached at abnormally low workloads. The Chester Step Test + pulse oximeter captures this non-invasively at home.
28–50% of PACVS patients meet criteria for POTS or orthostatic hypotension. The NASA Lean Test — lying for 10 minutes then standing — detects this using only your pulse oximeter and a wall.
A mix of objective devices and validated self-report instruments. Total weekly time commitment: under 15 minutes.
Fasting NO strip photographed via app. Tracks enterosalivary NO pathway response to the arginine/citrulline stack over 12 weeks.
Progressive stair-step protocol to estimate VO₂ max. Pulse ox logs SpO₂ + HR throughout. Captures exertional desaturation and heart rate recovery.
Lie 10 min → stand against wall → pulse ox records HR at 1, 3, 5, 10 min. Detects POTS (≥30 bpm rise) and orthostatic hypotension.
5 items, under 60 seconds. Fatigue, brain fog, PEM, sleep, and pain — logged each morning via the app. Captures within-person variation missed by weekly surveys.
DePaul Symptom Questionnaire PEM subscale. The most specific validated instrument for post-exertional malaise — our primary outcome measure.
Validated fatigue and functional capacity scales used in PACVS and ME/CFS research worldwide. Required for IRB-accepted quality-of-life endpoints.
This pilot is for adults experiencing persistent symptoms following COVID-19 vaccination.
Submit your expression of interest below. We'll send a screening questionnaire within 48 hours. Once you qualify and sign the informed consent form, you'll receive payment and shipping details.
Your three bags arrive within 7–10 days. Set up the Wellue app, complete your baseline NASA Lean Test, Chester Step Test, NO strip, and symptom questionnaires. This is your Day 1 data anchor.
Daily supplement dose + 60-second symptom check-in. Weekly salivary NO strip (fasting, photographed via app). Monthly Chester Step Test + NASA Lean Test + questionnaire battery.
Repeat the full baseline assessment battery at Week 12. Receive your personal results report comparing your baseline to endpoint across all measures. Data contributes to OSMF's peer-reviewed publication.
Formulated to target the two core mechanistic pathways in PACVS: nitric oxide bioavailability and mitochondrial oxidative capacity. All ingredients are GRAS-status, sourced from GMP-certified suppliers, with established safety profiles at these doses.
Each daily dose is a single powder blend, mixed in water or juice, taken each morning with food.
Product mockup — final product may differ in appearance.
Primary endpoint — weekly DePaul Symptom Questionnaire PEM subscale. Most specific validated instrument for PACVS.
VO₂ max estimate + exertional SpO₂ desaturation + heart rate recovery. Objective surrogate for mitochondrial function.
Weekly serial measurement of enterosalivary NO via test strip. Trajectory over 12 weeks reflects NO bioavailability response.
FACIT-Fatigue and SF-36 Physical Function subscale at baseline, 6 weeks, and 12 weeks.
Orthostatic HR response — detects POTS and orthostatic hypotension using only pulse ox.
Can't participate? Donate to fund kit costs for participants who need financial assistance — and to scale this trial to n=200.
Donations directly fund two things: subsidised participation for patients who need financial assistance, and the larger n=200 trial needed for publication in a high-impact journal.
OSMF is a non-profit research foundation currently being registered in Estonia. All research outputs are open access. No venture funding, no pharma sponsorship.
One-time or recurring · All amounts welcome
Participants receive the full 90-day supplement protocol (10 ingredients, pre-measured), a Wellue PC-60FW Bluetooth pulse oximeter, 13 salivary NO test strips, a protocol instruction card, and shipping to your door. You also receive 12 weeks of data collection support and a personal results report at completion. Participation costs and any financial assistance options will be discussed during the screening process.
No. This is a fully decentralized trial. Everything ships to your home. All measurements are done at home using the supplied equipment and your smartphone. There are no clinic visits, no lab appointments, and no travel required.
The protocol is designed with PEM-awareness at its core. The Chester Step Test uses a very low-intensity progressive protocol with clear stopping criteria — you stop immediately if symptoms worsen. All supplement ingredients have established safety profiles at the doses used. The screening questionnaire will flag any contraindications before enrollment is confirmed. We strongly recommend informing your primary care physician before participating.
Currently: United States, Canada, United Kingdom, EU member states, and Australia. Additional countries may be supported on request — contact us at contact@opensourcemed.info to enquire. Note that shipping times outside North America may extend kit delivery to 14–21 days.
No. This is an open-label single-arm pilot study — all 20 participants receive the active supplement protocol. This design is appropriate for a first-in-kind pilot where establishing safety, feasibility, and preliminary signal is the primary goal. A randomized controlled trial is planned as the follow-on study once pilot data is available.
Daily: supplement dose (1 min) + symptom check-in app (60 sec). Weekly: salivary NO strip + photo upload (5 min). Monthly: Chester Step Test + NASA Lean Test + questionnaire battery (~25 min). Total weekly average: approximately 10–15 minutes. The monthly assessment day requires the most effort — plan a low-exertion day around it.
This study is sponsored by the Open Source Medicine Foundation (OSMF), an Estonian MTÜ operating within Próspera ZEDE, Roatán, Honduras. Ethics review is currently underway with the CEIB (Comité de Ética en Investigación Biomédica) at UNAH's Faculty of Medical Sciences in Tegucigalpa, Honduras — an OHRP-registered IRB (No. 00003070). ClinicalTrials.gov registration under OSMF sponsorship is in progress. Enrollment will not open until ethics approval is confirmed. Scientific oversight details will be published ahead of enrollment.
VitalScan4PACVS builds on foundational investigator-initiated research in metabolic modulation for post-acute COVID vaccination syndrome. The study is now fully sponsored and conducted by OSMF under a redesigned decentralized protocol. OSMF holds full scientific and operational responsibility for this trial.
All data is pseudonymised — your name is replaced with a participant ID for all analysis. Anonymised aggregate data will be published open-access. You will receive a personal report of your own results. Data is stored securely and never sold or shared with third parties. Full details in the informed consent form.
Join the first fully decentralized PACVS trial. Help generate the evidence base this community deserves.